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. 2023 Jul 10;112(12):1800–1811. doi: 10.1007/s00392-023-02255-8

Table 3.

Subgroup analysis of older age (> 70 years) and high stroke risk (CHA2DS2-VASc-Socre ≥ 3 in all patients

Total cohort
SR [n (%)] POAF [n (%)] HR [95% CI] p value
Age
 Age ≤ 70 159 53
  Composite endpoint 29 (18.2) 14 (26.4) 1.6 [0.81; 3.00] 0.18
   All-cause mortality 12 (7.6) 6 (11.3) 1.5 [0.55; 4.07] 0.43
   Stroke 5 (3.1) 4 (7.6) 2.5 [0.65; 9.53] 0.19
   Rehospitalization 14 (8.8) 7 (13.2) 1.7 [0.68; 4.39] 0.25
 Age > 70 171 103
  Composite endpoint 38 (22.2) 32 (31.1) 1.5 [0.94; 2.42] 0.09
   All-cause mortality 25 (14.6) 26 (25.2) 1.8 [1.06; 3.18] 0.031
   Stroke 9 (5.3) 6 (5.8) 1.2 [0.42; 3.29] 0.77
   Rehospitalization 5 (2.9) 8 (7.8) 2.8 [0.91; 8.55] 0.07
Stroke risk
 CHA2DS2-VASc-score < 3 121 55
  Composite endpoint 15 (12.4) 8 (14.6) 1.2 [0.49; 2.78] 0.74
   All-cause mortality 4 (3.3) 6 (10.9) 3.2 [0.89; 11.39] 0.08
   Stroke 4 (3.3) 1 (1.8) 0.6 [0.06; 4.95] 0.59
   Rehospitalization 7 (5.8) 2 (3.6) 0.7 [0.14; 3.41] 0.65
 CHA2DS2-VASc-score ≥ 3 209 101
  Composite endpoint 52 (24.9) 38 (37.6) 1.7 [1.09; 2.53] 0.018
   All-cause mortality 33 (15.8) 26 (25.7) 1.7 [1.03; 2.88] 0.039
   Stroke 10 (4.8) 9 (8.9) 2.0 [0.81; 4.94] 0.13
   Rehospitalization 12 (5.7) 13 (12.9) 2.5 [1.14; 5.50] 0.022

HR, hazard ratio, POAF, perioperative atrial fibrillation, SR, sinus rhythm

Bold value indicates p-values < 0.05 were considered statistically significant