Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 5;14:8054. doi: 10.1038/s41467-023-43623-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a HA synthesis and degradation pathway. Genes responsible for each enzymatic reaction are labeled in green. F6P Fructose 6-phosphate, GlcN6P Glucosamine-6-phosphate, GlcNAc6P N-acetyl-glucosamine 6-phosphate, GlcNAc1P N-acetyl-glucosamine 1-phosphate, UDP-GlcNAc Uridine diphosphate N-acetylglucosamine, G6P Glucose 6-phosphate, G1P Glucose 1-phosphate, UDP-G Uridine diphosphate glucose, UDP-GlcUA Uridine diphosphate glucuronic acid. b Heatmap showing the expression fold changes for HA-related genes. Genes are grouped into six sets corresponding to their function, including HA substrate metabolic pathways (UDP-GlcNAc synthesis and UDP-GlcUA synthesis), HA synthesis, HA degradation, HA binding, and TNFAIP6 related genes. The fold change values were calculated by comparing each subterranean species to their closest aboveground species. For tissues where the closest aboveground species samples are not available, rat samples were used. c Diagram on top shows the domain structure of HYAL2 and corresponding Bayes Empirical Bayes posterior probabilities (PP) of positive selection in the common ancestor of SNM and EM, with sites predicted to be under positive selection in blue (PP > 0.5). Amino acid alignment of the positively selected sites is shown below. S: Signal peptide. GHF Glycoside hydrolase family 56 (Pfam). EGF EGF-like domain. d Convergent amino acid replacements between BMR and DMR or between NMR and EM. e Diagram showing the disruptive mutations identified in GHF domain of HYAL3 of BMR and two closely related species, Bamboo rat and Plateau zokor. Red bars: indel; Blue bars: stop-codon.