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. 2023 Dec 5;13:21454. doi: 10.1038/s41598-023-48830-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Survival of 1082 patients with ER + /HER2- breast cancer based on EERES, as determined by GSVA using the Hallmark Estrogen Response Early MSigDB gene set. (a) Scatter plot of ESR1 gene expression and EERES of ER + /HER2- (blue) breast cancer and TNBC (yellow) tumor samples. (b) PFS and (c) OS durations of ER + /HER2- breast cancer and TNBC tumor samples, tested with log-rank tests and shown as Kaplan–Meier curves. ER + /HER2- breast cancer tumor samples were stratified into higher and lower EERES, as described in the Methods, and their (d) PFS and (e) OS durations are shown as Kaplan–Meier curves.