Graphical representation of synaptic density in the hippocampal CA1 region of the ovariectomized rats. EControl, group of rats that received propylene glycol early; LControl, group of rats that received propylene glycol late; EEstr, group of rats that received estrogen early; LEstr, group of rats that received estrogen late; ERLX, group of rats that received raloxifene early; LRLX, group of rats that received raloxifene late. Population distribution was analyzed by the Kolmogorov-Smirnov test. One-way ANOVA and the post hoc Tuckey test were performed for comparing the groups. a p < 0.001 compared to LContr, EEstr, and ERLX; b p < 0.001 compared to EEstr, LEstr, ERLX, and LRLX; c p < 0.001 compared to LEstr, ERLX, LRLX; d p < 0.001 compared to ERLX; e p < compared to LRLX. F value is 254,5.