Table 1.
Characteristics of patients with detectable anti-HCV on ED screening, and univariate and multivariate analysis of risk factors in relation to the HCV RNA detection.
| Anti-HCV positive (N = 684) | Undetectable HCV RNA (n = 556) | Detectable HCV RNA (n = 128) | Univariate analysis p value∗ | Multivariate analysis |
||
|---|---|---|---|---|---|---|
| OR (95% CI) | p value | |||||
| Men, n (%) | 342 (50) | 283 (51) | 59 (46) | 0.3 | ||
| Age (year), median (IQR) | 72 (55–86) | 71 (55–86) | 79 (53–88) | 0.3 | ||
| White, n (%) | 630 (93) | 510 (92) | 120 (94) | 0.4 | ||
| IDU (current or history), n (%) | 125 (18) | 92 (17) | 33 (26) | 0.02 | 4.9 (2.3–10.5) | <0.001 |
| Alcohol consumption, n (%) | 156 (22) | 124 (22) | 32 (25) | 0.5 | ||
| Prior blood product transfusion, n (%) | 45 (7) | 30 (5) | 15 (12) | 0.01 | 2.4 (1.2–4.8) | 0.02 |
| Psychiatric disorder, n (%) | 257 (38) | 209 (38) | 48 (38) | 0.9 | ||
| HIV coinfection, n (%) | 74 (11) | 58 (10) | 6 (4) | 0.5 | ||
| Unaware of infected status, n (%) | 270 (39) | 226 (41) | 44 (34) | 0.1 | ||
| HBsAg, n (%) | 5 (0.7) | 5 (0.9) | 0 (0) | 0.4 | ||
| ALT (IU/L), median (IQR) | 18 (12–30) | 17 (12–27) | 29 (17–56) | <0.001 | ||
| FIB-4, median (IQR) | 2.31 (1.46–3.69) | 2.23 (1.4–3.12) | 3.3 (1.78–6) | <0.001 | ||
| Advanced fibrosis (FIB-4 >3.25), n (%) | 206 (30) | 141 (25) | 65 (51) | <0.001 | ||
| Hepatocellular carcinoma, n (%) | 26 (4) | 16 (3) | 10 (8) | <0.001 | ||
Quantitative variables were expressed as medians (IQR) because of the non-normality of the distributions previously tested with a normality test (Shapiro–Wilks). To compare qualitative variables in univariate analysis, a Chi-square test was used, and Fisher's exact test was used in those expected frequencies <5. In the univariate comparison of quantitative variables, owing to non-normality, the Wilcoxon–Mann–Whitney U test was used. For the multivariate study, logistic regression was used, the independent variable being HCV RNA detectability or not. For all statistical studies, statistical significance was considered at p <0.05.
anti-HCV, HCV antibody; ED, emergency department; FIB-4, Fibrosis-4; IDU, injecting drug use.
Comparison between patients with detectable and undetectable HCV RNA. P-values and ORs with statistical significance for a p-value of less than 0.05 are marked in bold.