Table 1.
Global burden of cirrhosis and other chronic liver diseases due to nonalcoholic fatty liver disease in 204 countries and territories from 1990 to 2019
| Characteristics |
Death (95%UI)
|
Prevalence (95%UI)
|
DALYs (95%UI)
|
||||||
|
2019
|
2019
|
1990-2019
|
2019
|
2019
|
1990-2019
|
2019
|
2019
|
1990-2019
|
|
|
Death cases among COCLDs due to NAFLD
|
ASDR per 100000 population (95%UI)
|
EAPC (95%CI)
|
Prevalence cases among COCLDs due to NAFLD
|
ASPR per 100000 population (95%UI)
|
EAPC (95%CI)
|
DALY cases among COCLDs due to NAFLD
|
ASDAR per 100000 population (95%UI)
|
EAPC (95%CI)
|
|
| Global | 134240.56 (96483.10-176920.13) | 1.66 (1.20-2.17) | -0.65 (-3.68-2.48) | 1235652879.48 (1109501987.09-1378481210.81) | 15022.90 (13493.19-16764.24) | 0.78 (0.74-0.82) | 3621471.92 (2585375.27-4862918.36) | 43.69 (31.28-58.38) | -0.73 (-1.33 to -0.13) |
| Sex | |||||||||
| Male | 72379.97 (51296.70-98029.91) | 1.91 (1.36-2.54) | -0.62 (-3.46-2.31) | 679261655.31 (610650033.21-753716195.72) | 16789.38 (15136.45-18609.47) | 0.77 (0.74-0.81) | 2111194.29 (1490236.02-2905285.80) | 52.39 (37.17-71.63) | -0.65 (-1.20 to -0.10) |
| Female | 61860.58 (44641.50-81216.17) | 1.42 (1.03-1.86) | -0.70 (-3.95-2.66) | 556391224.17 (499050879.21-624989968.22) | 13278.47 (11900.05-14925.95) | 0.78 (0.74-0.82) | 1510277.64 (1087564.54-1984959.30) | 35.16 (25.35-46.24) | -0.84 (-1.49 to -0.18) |
| SDI | |||||||||
| Low SDI | 12175.43 (8552.07-16892.87) | 2.41 (1.65-3.38) | -1.04 (-3.48-1.45) | 108176159.27 (95419333.67-122650081.72) | 14278.53 (12741.85-16053.31) | 0.34 (0.30-0.38) | 367698.76 (255871.37-510346.73) | 59.56 (41.46-82.97) | -1.14 (-1.63 to -0.65) |
| Low-middle SDI | 28042.90 (20040.37-37459.68) | 2.09 (1.52-2.77) | -0.73 (-3.47-2.08) | 245742808.24 (219055120.10-276667118.34) | 15232.77 (13662.46-17078.41) | 0.56 (0.52-0.59) | 826708.77 (584688.97-1130359.54) | 54.77 (39.14-74.11) | -0.86 (-0.31 to -1.4) |
| Middle SDI | 51854.16 (37473.84-68073.39) | 2.23 (1.62-2.92) | -0.77 (-3.35-1.88) | 464259979.22 (417290788.31-516020477.89) | 17596.41 (15842.14-19525.24) | 0.66 (0.62-0.69) | 1347118.90 (956498.31-1772557.91) | 52.41 (38.16-68.22) | -0.98 (-1.52 to -0.44) |
| Middle-high SDI | 25074.30 (18164.41-33237.26) | 1.27 (0.93-1.67) | -0.75 (-4.08-2.69) | 278080918.57 (251203100.31-308471139.19) | 15336.20 (13798.84-17095.00) | 0.79 (0.75-0.83) | 676567.46 (480709.11-915257.33) | 34.81 (25.11-46.87) | -0.52 (-1.16-0.14) |
| High SDI | 16984.00 (12138.02-22893.89) | 0.95 (0.67-1.30) | -0.79 (-4.75-3.33) | 138619942.87 (125499384.96-153306375.41) | 10528.91 (9426.64-11724.43) | 1.22 (1.17-1.26) | 400520.00 (273854.75-550359.22) | 25.46 (17.47-35.02) | -0.84 (-1.61 to -0.05) |
| Region | |||||||||
| Andean Latin America | 2935.06 (2012.67-4051.53) | 5.31 (3.62-7.30) | -0.23 (-1.96-1.54) | 8442278.35 (7603147.20-9329779.19) | 13689.71 (12376.75-15086.12) | 0.50 (0.47-0.54) | 70058.17 (47362.01-98970.21) | 121.70 (82.37-172.61) | -0.69 (-1.05 to -0.34) |
| Australasia | 413.12 (297.05-538.48) | 0.87 (0.63-1.13) | -0.22 (-4.56-4.32) | 3459804.59 (3121214.49-3821041.92) | 9444.14 (8455.34-10478.02) | 0.91 (0.86-0.95) | 9514.38 (6661.05-12694.41) | 22.52 (15.80-30.52) | -0.22 (-1.09-0.65) |
| Caribbean | 1607.95 (1113.98-2236.69) | 3.11(2.15-4.30) | -0.71 (-3.01-1.65) | 8176172.43 (7382389.69-9017056.63) | 16169.48 (14591.11-17866.53) | 0.40 (0.37-0.43) | 41576.95 (28066.48-60045.06) | 80.64 (54.52-115.96) | -0.75 (-1.21 to -0.29) |
| Central Asia | 2633.58 (1802.74-3693.53) | 3.56 (2.51-4.95) | 2.00 (-0.39-4.45) | 12814865.72 (11452914.10-14330325.35) | 14150.39 (12737.16-15748.23) | 0.50 (0.46-0.54) | 84039.15 (57215.03-120570.79) | 97.76 (67.81-137.00) | 1.97 (1.51-2.43) |
| Central Europe | 2061.07 (1378.12-2972.76) | 1.05 (0.71-1.49) | -0.36 (-4.12-3.56) | 18627848.59 (16912570.59-20480313.45) | 11894.85 (10754.82-13109.51) | 0.34 (0.30-0.38) | 54731.91 (36055.44-79057.76) | 30.45 (19.95-43.92) | -0.35 (-1.06-0.37) |
| Central Latin America | 13972.52 (10310.77-18101.39) | 5.90 (4.32-7.66) | -0.61 (-2.24-1.06) | 42166216.88 (37817332.61-46840542.82) | 16617.99 (14959.55-18388.64) | 0.43 (0.40-0.46) | 379421.91 (275350.09-504051.39) | 154.08 (112.26-204.63) | -0.84 (-1.16 to -0.52) |
| Central Sub-Saharan Africa | 1464.95 (913.12-2215.29) | 2.71 (1.74-4.05) | -0.79 (-3.19-1.67) | 11343938.83 (9886866.10-12995919.12) | 13331.21 (11795.46-15097.36) | 0.16 (0.13-0.20) | 47553.59 (29400.33-74006.26) | 70.04 (43.82-106.28) | -0.78 (-1.26 to -0.30) |
| East Asia | 15620.62 (11027.12-21039.77) | 0.80 (0.58-1.07) | -2.35 (-6.22-1.68) | 303112259.13 (272363603.29-339481359.63) | 15680.86 (14022.56-17552.19) | 0.85 (0.81-0.89) | 391872.94 (268774.96-535743.63) | 18.91 (13.28-25.56) | -2.71 (-3.50 to -1.91) |
| Eastern Europe | 7354.24 (5071.40-10094.04) | 2.41 (1.67-3.30) | 3.04 (0.05-6.12) | 34110583.23 (30980982.64-37557624.89) | 12295.07 (11098.49-13601.74) | 0.39 (0.35-0.42) | 245483.77 (166670.25-344145.21) | 85.82 (58.40-120.98) | 3.58 (3.06-4.11) |
| Eastern Sub-Saharan Africa | 6094.93 (4211.94-8428.57) | 3.98 (2.74-5.49) | -0.66 (-2.62-1.34) | 36093305.19 (31609582.82-41132257.66) | 13709.06 (12222.30-15370.26) | 0.29 (0.26-0.33) | 175459.64 (119576.20-250541.44) | 91.96 (62.83-129.95) | -0.82 (-1.22-0.41) |
| High-income Asia Pacific | 1462.94 (990.41-2089.17) | 0.31 (0.21-0.42) | -3.18 (-8.97-2.97) | 20933934.70 (18773194.85-23278277.91) | 7671.66 (6829.94-8629.15) | 0.56 (0.51-0.61) | 26564.50 (18456.53-35825.79) | 7.20 (4.90-9.83) | -3.36 (-4.57 to -2.14) |
| High-income North America | 7014.45 (4867.08-9682.42) | 1.20 (0.83-1.63) | 0.34 (-3.56-4.39) | 44312078.16 (39693504.66-49544059.79) | 9395.90 (8403.86-10542.43) | 0.98 (0.94-1.03) | 178065.34 (120160.62-251423.01) | 33.23 (22.97-46.98) | 0.36 (-0.40-1.12) |
| North Africa and Middle East | 11756.00 (7699.85-17161.92) | 3.18 (2.07-4.60) | -0.35 (-2.59-1.94) | 161456578.66 (146407605.69-177659074.34) | 27748.49 (25409.87-30283.48) | 0.47 (0.45-0.50) | 265596.53 (171336.92-375177.75) | 61.14 (39.58-87.12) | -0.31 (-0.83-0.21) |
| Oceania | 87.79 (55.51-129.24) | 1.13 (0.77-1.60) | -0.17 (-3.94-3.75) | 1744101.91 (1541892.36-1965419.91) | 16869.18 (15133.44-18726.79) | 0.18 (0.15-0.21) | 3194.63 (1975.61-4878.17) | 33.00 (20.97-48.54) | -0.21 (-0.91-0.50) |
| South Asia | 17739.51 (12596.43-24044.26) | 1.28 (0.90-1.73) | -1.55 (-4.85-1.87) | 241838470.86 (214848138.41-273682478.00) | 14513.87 (12969.20-16400.60) | 0.55 (0.51-0.58) | 546376.19 (385933.87-757708.62) | 34.54 (24.64-47.48) | -1.76 (-2.41 to -1.11) |
| Southeast Asia | 19624.56 (13971.70-26356.88) | 3.43 (2.46-4.62) | -0.23 (-2.40-1.99) | 128065513.81 (114729541.70-142457456.46) | 18299.21 (16508.63-20309.58) | 0.46 (0.42-0.49) | 539043.89 (379432.49-734864.03) | 82.56 (58.82-110.61) | -0.58 (-1.01 to -0.14) |
| Southern Latin America | 1429.48 (982.16-1989.97) | 1.73 (1.18-2.41) | -0.18 (-3.30-3.02) | 6483740.60 (5831421.14-7191963.86) | 8602.52 (7719.35-9564.23) | 0.90 (0.85-0.95) | 34294.28 (22901.01-48792.78) | 42.86 (28.61-61.04) | -0.52 (-1.14-0.11) |
| Southern Sub-Saharan Africa | 888.05 (632.75-1213.53) | 1.61 (1.14-2.18) | -0.53 (-3.41-2.44) | 13161620.39 (11810250.76-14681736.21) | 18075.91 (16347.92-19997.66) | 0.41 (0.37-0.44) | 26198.48 (18261.46-36311.83) | 40.87 (28.84-55.60) | -0.69 (-1.26 to -0.12) |
| Tropical Latin America | 4447.37 (3232.26-5827.27) | 1.84 (1.35-2.40) | -0.44 (-3.42-2.63) | 37986300.10 (34231442.55-41945927.58) | 15241.19 (13723.17-16818.90) | 0.49 (0.45-0.52) | 120114.10 (85232.80-161026.13) | 48.00 (34.37-63.83) | -0.60 (-1.18 to -0.02) |
| Western Europe | 9604.81 (6833.82-12825.54) | 1.09 (0.78-1.46) | -1.81 (-5.22-1.72) | 59002155.13 (53307928.02-65208561.44) | 9932.86 (8931.95-11044.15) | 0.80 (0.76-0.85) | 201120.00 (140612.13-273526.30) | 26.97 (18.77-37.08) | -2.03 (-2.72 to -1.35) |
| Western Sub-Saharan Africa | 6027.57 (4018.12-8572.80) | 3.31 (2.21-4.67) | -0.67 (-2.78-1.48) | 42321112.21 (37193511.05-48136808.11) | 14283.82 (12756.86-15952.84) | 0.22 (0.18-0.25) | 181191.57 (116196.70-270466.76) | 79.06 (51.99-113.80) | -0.70 (-1.13 to -0.26) |
ASDAR: Age-standardized disability-adjusted life-years rate; ASDR: Age-standardized death rate; ASPR: Age-standardized prevalence rate; CI: Confidence interval; COCLD: Cirrhosis and other chronic liver diseases; DALYs: Disability-adjusted life-years; EAPC: Estimated annual percentage change; NAFLD: Nonalcoholic fatty liver disease; SDI: Sociodemographic index; UI: Uncertainty interval.