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SARS-CoV-2 trimeric S IgG antibody concentration (log-transformed values) 6 months (T6) and 12 months (T12) after first dose of vaccine. Data are stratified according to anti-N IgG positivity at T12 and presented for healthy adults ≤ 65 years of age (under 65, A, B) and frail elderly > 65 years of age (65+, C, D). Mean values in each group are indicated (thick lines).
