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. 2023 Nov 16;11(32):7895–7899. doi: 10.12998/wjcc.v11.i32.7895

Table 1.

Timelines of patient events and medications in current admission and follow-up

Date
Event
Medication/s
Comment
July 2008 Hospitalization ROS 4 mg/d First onset with delusion and auditory hallucination
November 2009 TD ROS 4 mg/d + Alp 0.4 mg qn + GBE Psychotic symptoms resolved, but her bucco-linguo-masticatory syndrome appeared and could not be relieved by GBE
November 09-18, 2010      Que 0.2 g/d + Alp 0.4 mg qn + GBE 1 tab bid + Vit E 0.1/d TD was not relieved by switching ROS to Que and combining it with GBE and Vit E
November 19, 2011      Ola 10 mg/d + Alp 0.4 mg qn + GBE 1 tab bid + Vit E 0.1/d TD was not relieved by switching Que to Ola and combining it with GBE and Vit E
October 12, 2020 Readmission Ola 10 mg/d + PTZ 25 mg bid + THP 2 mg bid TD was not relieved by a combination of PTZ and THP during hospitalization
October 21, 2020-June 08, 2022      Que 0.2 g/d + PTZ 25 mg bid + Vit E 0.1/d TD was not relieved by switching to Que and combining it with PTZ and Vit E
June 09-11, 2022 Readmission Que 0.1 bid + DTB 6 mg bid + Vit E 0.1/d + PTZ 50 mg tid + Alp 0.4 mg qn TD was slightly ameliorated when administered in combination with DTB after admission; however, her tongue could not be retracted into the mouth. Video 1 (June 10, 2022). Baseline: AIMS 31, PANSS 56, CGI 7. D3: AIMS 29, PANSS 56, CGI 6
June 12-15, 2022 Clo 25 mg/d + DTB 6 mg bid + Vit E 0.1/d + PTZ 25 mg tid + Lor 1 mg qn TD was relieved remarkably after switching Que to Clo, and her tongue could now be retracted into the mouth. Video 2 (June 14. 2022) D7: AIMS 23, PANSS 52, CGI 4
July 16-19, 2021 Clo 25 mg bid + DTB 6 mg bid + Vit E 0.1/d + PTZ 25 mg qn + Lor 1 mg qn + MECT for the first session TD was ameliorated after combining MECT, and the tremor in her lower jaw was reduced. D10: AIMS 22, PANSS 48, CGI 3
July 20-22, 2021 Clo 25 mg bid + DTB 6 mg bid + Vit E 0.1/d + MECT for the second session TD did not worsen after stopping Lor and PTZ
July 23, 2021 Discharge D14: AIMS 20, PANSS 48, CGI 3
July 24, 2021-now Clo 25 mg bid + DTB 6 mg bid TD did not worsen after stopping Vit E, and she could take a semi-fluid diet. Video 3 (December 26, 2022). D182: AIMS 20, PANSS 46, CGI 3

AIMS: Abnormal involuntary movement scale; Alp: Alprazolam; Clo: Clozapine; DTB: Deutetrabenazine; GBE: Ginkgo biloba extract; Lor: Lorazepam; MECT: Modified electroconvulsive therapy; Ola: Olanzapine; PANSS: Positive and Negative Syndrome Scale; PTZ: Promethazine; Que: Quetiapine; ROS: Risperidone oral solution; TD: Tardive dyskinesia; THP: Trihexyphenidyl; Vit E: Vitamin E.