Reagents/Resource	Reference of source	Identifier or catalog number
Drosophila disease models
AD model	Bloomington Drosophila Stock Center	BL33769
HD model	Bloomington Drosophila Stock Center	BL33808
SCA1 model	Bloomington Drosophila Stock Center	BL39740
SCA3 model	Bloomington Drosophila Stock Center	BL8150
Drosophila RNAi lines
Droj2	Bloomington Drosophila Stock Center	BL36089
Akt1	Bloomington Drosophila Stock Center	BL31701
Atg1	Bloomington Drosophila Stock Center	BL26731
Uba1	Bloomington Drosophila Stock Center	BL36307
InR	Bloomington Drosophila Stock Center	BL31037
Par‐1	Bloomington Drosophila Stock Center	BL32410
Pdk1	Bloomington Drosophila Stock Center	BL27725
Mi‐2	Bloomington Drosophila Stock Center	BL33419
Lk6	Bloomington Drosophila Stock Center	BL28357
Hsc70Cb	Bloomington Drosophila Stock Center	BL33742
Zip	Bloomington Drosophila Stock Center	BL36727
sgg	Bloomington Drosophila Stock Center	BL35364
Cyp6a18	Bloomington Drosophila Stock Center	BL42824
CG34372	Bloomington Drosophila Stock Center	BL51472
Pi3k92E	Bloomington Drosophila Stock Center	BL61182 (AD, HD, SCA1) and BL35798 (SCA3) since BL61182 was lethal in SCA3.
Drosophila overexpression lines
Akt1	Bloomington Drosophila Stock Center	BL8191
Plasmid DNAs
pEGFP‐C1‐Aβ1‐42 constructed from pCAX‐FLAG‐APP	Addgene	#30154
pEGFP‐Htt‐exon1‐Q74	Addgene	#40262
pEGFP‐Ataxin1‐52Q	Addgene	#32492
pEGFP‐C1‐Ataxin3‐Q84	Addgene	#22123
Human cell line
HEK293	ATCC	CRL‐1573
Animals
5xFAD mice	The Jackson Laboratory	034848‐JAX
Reagents
SC79	Sigma‐Aldrich	SML0749
Databases
NeuroGeM	https://neurogem.msl.ubc.ca/
GeneOntology	http://geneontology.org/
KEGG	https://www.genome.jp/kegg
InterPro	https://www.ebi.ac.uk/interpro/
Gene Regulation	http://droidb.org/
GEO	https://www.ncbi.nlm.nih.gov/geo/
UniProt	https://www.uniprot.org/
STRING	https://string‐db.org/
Neurocarta	https://gemma.msl.ubc.ca/phenotypes.html
GeneMania	https://genemania.org/
Tools
DAVID	https://david.ncifcrf.gov/