The antiproliferative activity of initial analogs against HeLa cells.

Compound	HeLa IC50a,b (μM)	cLogPc
8	0.044 ± 0.011	3.3
13	0.95 ± 0.35	3.7
14	>1.0	3.2
17	0.97 ± 0.23	3.3
20	0.37 ± 0.10	2.8
23	0.24 ± 0.06	2.6

^aData represent the mean of three independent determinations from triplicate samples.

^bIC₅₀ values were determined using the CCK-8 assay in HeLa cells.

^c cLogP values were calculated using online ALOGPS 2.1 program.