Mouse pharmacokinetic parameters of compounds 44 and 47.

Compound	i.v.a (2 mg kg−1)				p.o.b (10 mg kg−1)
	AUClast (μg h mL−1)	t 1/2 (h)	CL (L h−1 kg−1)	Vss (L kg−1)	AUClast (μg h mL−1)	C max (μg mL−1)	t 1/2 (h)	F %
44	0.77 ± 0.04	7.05 ± 1.92	2.58 ± 0.15	1.89 ± 0.31	0.94 ± 0.16	1.54 ± 0.33	5.45 ± 1.48	24
47	0.84 ± 0.11	1.69 ± 1.09	2.39 ± 0.32	3.23 ± 0.81	4.88 ± 2.07	2.88 ± 1.22	2.30 ± 0.23	116

^aDosed at 2 mg kg⁻¹ for i. v. administration of ICR mouse (n = 3, mean ± SD) in 5% DMSO/40% PEG400/55% DW (5 mL kg⁻¹).

^bDosed at 10 mg kg⁻¹ for p. o. administration of ICR mouse (n = 3, mean ± SD) in 5% DMSO/40% PEG400/55% DW (5 mL kg⁻¹).