Fig. 14. (A) Structure of noncovalent inhibitors of SARS-CoV-2 Mpro, containing an isoquinoline ring and a bromophenyl ring. (B) The binding of noncovalent inhibitor WU-04 into the catalytic pocket of SARS-CoV-2 Mpro. (C) Seven hit analogs of WU-04 and their inhibitory activity against SARS-CoV-2 Mpro evaluated using the fluorescent assay. Adapted with permission from ref. 96. Copyright © 2023 The Authors. Published by American Chemical Society.
