| Nsp1 |
Ensures RNA processing and replication (PDB: 6ZOK, 2GDT) |
| Nsp2 |
Modulates the host cell survival signalling pathway (PDB: 7EXM) |
| Nsp3 |
Separates proteins that are translated (PLpro) (PDB: 6W02, 5Y3E) |
| Nsp4 |
Contains a transmembrane domain (TM2) and modifies membranes |
| Nsp5 |
The main protease (Mpro), participates in the process of cleavage of polyprotein during replication (PDB: 1WOF, 1Z1J, 2C3C) |
| Nsp6 |
Is the transmembrane domain |
| Nsp7 |
Has an effect on RNA-dependent RNA polymerase (PDB: 1YSY) |
| Nsp8 |
The presence of nsp7, nsp8, and nsp11 affects RNA-dependent RNA polymerase and coronavirus replication/transcription |
| Nsp9 |
Functioning as an ssRNA-binding protein |
| Nsp10 |
Is crucial for cap-methylation of viral mRNAs (PDB: 2G9T) |
| Nsp11 |
Together with nsp7, nsp8 targets RNA-dependent RNA polymerase and coronavirus replication/transcription |
| Nsp12 |
Contains RNA-dependent RNA polymerase (RdRp), which is a critical component of coronavirus replication/transcription |
| Nsp13 |
The zinc-binding domain of nsp13 is involved in replication and transcription processes (PDB: 6XEZ, 7EIZ) |
| Nsp14 |
Proofreading exoribonuclease domain |
| Nsp15 |
Has Mn2+-dependent endoribonuclease activity (PDB: 6VWW) |
| Nsp16 |
2′-O-ribosemethyltransferase (PDB: 6WKS) |
