Table 3.

Association of cardiometabolic traits and obesity-related biomarkers with HFpEF

	MV-adjusted model
	OR (95% CI)	p-value
Cardiometabolic Traits
Diabetes	1.89 (1.04–3.41)	0.04
Obesity	1.96 (1.30−2.96)	0.001
BMI	1.06 (1.03−1.10)	<0.001
Obesity-Related Biomarkers
CRP	1.25 (1.03−1.52)	0.03
IL-6	1.15 (0.95−1.40)	0.16
HOMA-IR	1.26 (0.98−1.62)	0.07
Adiponectin	0.97 (0.79−1.19)	0.77
Leptin	1.36 (1.09−1.70)	0.007
Resistin	0.92 (0.75−1.11)	0.37
NT-pro BNP	1.54 (1.21−1.94)	<0.001

Odds ratio represents point estimate and 95% confidence interval of HFpEF per 1 unit change in BMI and per 1-SD unit change in log-transformed biomarkers in multivariable regression models adjusted for age, sex, hypertension, diabetes, current smoking, and previous myocardial infarction. Analyses for HOMA-IR excludes individuals with diabetes. Abbreviations: MV = multivariable; OR = odds ratio; CI = confidence interval; CRP = high-sensitivity C-reactive protein; IL-6 = interleukin-6; HOMA-IR= homeostatic model assessment of insulin resistance; NT-pro BNP = N-terminal pro-B-type natriuretic peptide.