Table 2.
Safety blood tests monitored in the study.
| Lab test | Baseline | On cholic acid | P value⁎ |
|---|---|---|---|
| Sodium (mmol/L) | 139 ± 2.5 | 139 ± 2.1 | 0.295 |
| Potassium (mmol/L) | 4.3 ± 0.29 | 4.4 ± 0.39 | 0.396 |
| Chloride (mmol/L) | 107 ± 2.02 | 104 ± 2.87 | 0.0168 |
| Carbon dioxide (meq/L) | 24.3 ± 2.70 | 22.9 ± 3.87 | 0.112 |
| Aspartate aminotransferase (U/L) | 43 ± 11 | 47 ± 16 | 0.515 |
| Alanine aminotransferase (U/L) | 34 ± 20 | 36 ± 14 | 0.813 |
| Alkaline phosphatase (U/L) | 138 ± 50 | 133 ± 47 | 0.568 |
| Gamma-glutamyl transferase (U/L) | 22 ± 19 | 22 ± 18 | 0.884 |
| Bilirubin (mg/dL) | 0.34 ± 0.14 | 0.29 ± 0.14 | 0.191 |
| Albumin (g/dL) | 4.5 ± 0.29 | 4.5 ± 0.36 | 0.690 |
| Total protein (g/dL) | 7.0 ± 0.44 | 7.1 ± 0.56 | 0.582 |
| Creatinine (mgdL) | 0.43 ± 0.294 | 0.42 ± 0.28 | 0.411 |
| Blood Urea Nitrogen (mg/dL) | 14 ± 3.1 | 14 ± 3.8 | 0.999 |
| Calcium (mg/dL) | 9.7 ± 0.35 | 9.7 ± 0.16 | 0.781 |
| 25-OH-Vitamin D (ng/ml) | 69.9 ± 26.4 | 77.9 ± 28.9 | 0.129 |
| White Blood Count ((x103/μL) | 8.39 ± 2.19 | 9.43 ± 2.91 | 0.194 |
| Hemoglobin (g/dL) | 13.9 ± 1.61 | 14.1 ± 1.57 | 0.427 |
| Hematocrit (%) | 41.5 ± 4.57 | 42.4 ± 4.18 | 0.225 |
| Platelets (x103/ μL) | 314 ± 101 | 369 ± 164 | 0.034 |
| Body weight (kg) | 28.1 ± 22.2 | 29.1 ± 23.0 | 0.069 |
⁎
Paired t-test.