Table 3.

Separate analysis for the primary outcomes.

	Studies	Effect size and 95% CI				Heterogeneity				Test for subgroup difference
		Effect size	95% CI		P-value	I2	95% PI		P-value
Adenoma miss rate (RR)
Pathology
Advanced adenoma miss rate (RR)	4	0.702	0.127	3.876	0.56	32.28%	0.015	33.429	0.32	0.59
Sessile serrated lesion miss rate (RR)	4	0.456	0.111	1.876	0.18	37.70%	0.018	11.426	0.23
Adenoma detection rate (RR)
Pathology
Advanced adenoma	13	1.132	1.016	1.261	0.028	38.33%	0.804	1.593	0.59	0.64
Sessile serrated lesion	12	1.001	0.849	1.180	0.99	31.66%	0.624	1.605	0.67
Non-neoplastic lesion	7	1.163	0.976	1.386	0.079	50.71%	0.764	1.771	0.13
Colorectal cancer	8	1.441	0.702	2.955	0.27	62.30%	0.203	10.237	0.40
Morphology
Polypoid	6	1.230	1.050	1.441	0.020	63.37%	0.768	1.969	0.46	0.27
Non-polypoid	8	1.419	1.204	1.671	0.0015	57.63%	0.864	2.330	0.46
Size category
0–5 mm	9	1.269	1.133	1.421	0.0013	62.34%	0.928	1.733	0.037	0.99
6–10 mm	9	1.238	1.009	1.520	0.043	75.76%	0.630	2.436	0.39
<10 mm	3	1.308	0.878	1.950	0.10	52.20%	0.163	10.488	0.34
>10 mm	11	1.287	0.984	1.684	0.063	83.66%	0.468	3.543	0.28
Location
Proximal colon	7	1.187	1.134	1.242	0.00010	9.79%	1.090	1.293	0.90	0.30
Distal colon	6	1.291	1.092	1.526	0.011	50.91%	0.866	1.925	0.24
Adenoma per colonoscopy (WMD)
Pathology
Sessile serrated lesion	4	0.001	−0.030	0.032	0.94	6.76%	−0.076	0.077	0.91	NA
Morphology
Polypoid	5	0.131	0.076	0.185	0.0026	4.21%	0.044	0.217	0.91	0.97
Non-polypoid	5	0.133	−0.053	0.319	0.11	84.87%	−0.335	0.621	0.0012
Size category
0–5 mm	3	0.223	−0.481	0.927	0.31	90.45%	−3.675	4.121	0.0060	0.027
6–10 mm	3	0.031	−0.017	0.079	0.11	7.29%	−0.154	0.216	0.68
<10 mm	5	0.175	0.031	0.319	0.028	48.07%	−0.137	0.487	0.085
>10 mm	6	0.017	−0.005	0.040	0.10	13.61%	−0.024	0.059	0.78
Location
Proximal colon	8	0.191	0.107	0.275	0.0010	63.19%	−0.019	0.402	0.00060	0.027
Distal colon	5	0.073	−0.028	0.173	0.12	52.62%	−0.154	0.299	0.092
Adenoma per colonoscopy (IRR)
Pathology
Advanced adenoma	19	1.057	0.856	1.304	0.59	76.86%	0.411	2.716	0.47	0.012
Sessile serrated lesion	16	1.133	0.895	1.434	0.28	72.60%	0.435	2.952	0.014
Non-neoplastic lesion	14	1.632	1.389	1.916	<0.0001	81.43%	0.928	2.87	<0.0001
Colorectal cancer	4	2.061	0.196	21.625	0.40	52.11%	0.005	808.073	0.25
Morphology
Polypoid	13	1.453	1.262	1.673	0.00010	78.86%	0.868	2.433	0.0023	0.80
Non-polypoid	13	1.517	1.18	1.95	0.0035	80.25%	0.578	3.981	0.0019
Size category
0–5 mm	12	1.576	1.288	1.929	0.00040	89.00%	0.783	3.173	<0.0001	0.076
6–10 mm	11	1.204	1.08	1.343	0.0035	24.57%	0.93	1.559	0.61
<10 mm	13	1.416	1.266	1.583	<0.0001	77.27%	0.982	2.041	<0.0001
>10 mm	13	1.223	0.979	1.528	0.072	64.18%	0.59	2.534	0.29
Location
Proximal colon	15	1.433	1.258	1.634	<0.0001	78.73%	0.895	2.296	<0.0001	0.97
Distal colon	13	1.438	1.255	1.648	0.00010	72.36%	0.922	2.243	<0.0001

CI, confidence interval; PI, prediction interval; RR, risk ratio; IRR, incidence rate ratios; WMD, weighted mean difference; NA, not applicable.