. 2023 Nov 2;20(12):6213–6225. doi: 10.1021/acs.molpharmaceut.3c00626

Table 1. Plasma NCA PK Parameters for LEN Following Intravenous Infusion Administration to Nonclinical Species^a ^b.

species	dose (mg/kg)^b	AUC_last (μM·h)	AUC_inf (μM·h)	CL (L/h/kg)	V_ss (L/kg)	t_1/2 (h)	MRT (h)
WH rat	3	53.2 ± 8.08	60.1 ± 9.79	0.045 ± 0.004	2.63 ± 0.37	42.6 ± 6.14	50.2 ± 4.38
beagle dog	1	18.9 ± 5.9	19.1 ± 6.1	0.057 ± 0.017	1.12 ± 0.12	19.3 ± 2.5	20.6 ± 6.4

Values are the mean ± SD from 3 animals. AUC_last = area under the concentration–time curve from 0 to the last quantified time point; AUC_inf = area under the concentration–time curve extrapolated to time infinity; CL = systemic clearance; MRT = mean residence time; NCA = noncompartmental analysis; t_1/2 = terminal elimination half-life; SD = standard deviation; V_ss = volume of distribution at steady state; WH = Wistar Han.

Doses were administered via a 30 min IV infusion.

Table 1. Plasma NCA PK Parameters for LEN Following Intravenous Infusion Administration to Nonclinical Speciesab.

Table 1. Plasma NCA PK Parameters for LEN Following Intravenous Infusion Administration to Nonclinical Species^a ^b.