Table 2. PK Parameters of LEN Following Subcutaneous Administration of LEN in Aqueous Suspension to Male WH Rats^abcde.

group ID	dose (mg/kg)b	dose volume (mL/kg)	AUC0–72 h (μM·h)	AUC0–672 h (μM·h)	AUClast (μM·h)	AUCinf (μM·h)	Cmax (μM)	Tmax (h)	t1/2 (h)	% of AUCinf on day 3	% of AUCinf on day 28	F%e
1	10	0.10	32.5 + 20.8	194 + 14	236 + 36	236 + 36	0.671 + 0.198	25 + 23	219 + 81	14	82	118 ± 18
2	30	0.30	20.6 ± 3.9	343 ± 63	663 ± 83	664 ± 83	0.724 ± 0.222	224 ± 97	263 ± 31	3	52	110 ± 14
3	100	1.0	68.0 ± 27.2	900 ± 89	1545c	1554c	1.91 ± 0.33	224 ± 97	397c	4	58c	78c
4	200	1.0 × 2d	180 ± 93	1498 ± 223	2499 ± 188	2517 ± 194	3.81 ± 1.08	120 ± 83	403 ± 50	7	60	63 ± 5

^aValues are the mean ± SD from 3 animals. AUC_0–72 h = 3-day AUC; AUC_0–672 h = 28-day AUC; SD = standard deviation.

^bFormulation concentration at 100 mg/mL LEN.

^cOnly mean value was reported because one animal died at 2112 h postdose. This animal had appeared normal at the daily regular check time of 2088 h.

^dTwo injections, each at a distinct site.

^eF% = total fraction dose released = 100 × dose-normalized SC AUC_inf-to-IV AUC_inf ratio.