Table 4. PK Parameters of LEN Following Subcutaneous Administration of LEN in a PEG/Water Solution Formulation to Male WH Rats^abc.

group ID	dose (mg/kg)	dose volume (mL/kg)	AUC0–72 h (μM·h)	AUC0–672 h (μM·h)	AUClast (μM·h)	AUCinf (μM·h)	Cmax (μM)	Tmax (h)	t1/2 (h)	% of AUCinf on day 3	% of AUCinf on day 28	mean F%c
21	50	0.12	7.86 ± 1.47	152 ± 49	774 ± 74	789 ± 61	0.469 ± 0.120	718 ± 257	1056 ± 504	0.68	13	79 ± 6
22	100	0.33	16.2 ± 6.2	216 ± 113	1330 ± 238	1340 ± 228	0.500 ± 0.138	1064 ± 257	1240 ± 281	0.71	9.4	67 ± 11
23	150	0.5	21.7 ± 3.6	282 ± 14	2160 ± 211	2190 ± 205	0.765 ± 0.092	1120 ± 194	1420 ± 403	0.63	8.2	73 ± 7
24	450	1.5	75.7 ± 12.1	926 ± 164	5360 ± 787	5400 ± 837	1.95 ± 0.306	840 ± 444	1330 ± 263	0.73	9.0	60 ± 9
25	200	0.33 × 2b	32.3 ± 4.7	507 gf± 147	2410 ± 60	2410 ± 60	1.09 ± 0.17	728 ± 256	647 ± 28	0.71	11	60 ± 1
26	300	0.5 × 2b	41.1 ± 1.3	550 ± 54	3630 ± 189	3660 ± 184	1.35 ± 0.09	896 ± 775	1110 ± 299	0.60	8.0	61 ± 3
27	900	1.5 × 2b	99.4 ± 22.2	1140 ± 239	8400 ± 1160	8620 ± 1250	2.22 ± 0.35	1288 ± 423	1360 ± 156	0.48	5.5	48 ± 7

^aValues are the mean ± SD from 3 animals. AUC_0–72 h = 3-day AUC; AUC_0–672 h = 28-day AUC; SD = standard deviation.

^bTwo injections, each at a distinct site

^cF% = Total fraction dose released = 100 × dose-normalized SC AUC_inf-to-IV AUC_inf ratio.