Table 6. PK Model-Informed Release Rates and Total Fraction Dose Release^abcde.

			systemic elimination	SC depot release via direct process			SC depot release via indirect process
formulation	species	dose	kelimination (h–1)	kdirect (h–1)	t1/2 (days)b	Fracdirect	kindirect (h–1)	t1/2 (days)b	Tlag/MTT (days)	Fracindirect	F%c
aqueous suspension (100 mg/mL)	rat	10 mg/kg	0.016	0.018	1.6	0.09	0.00309	9.3	6.5d	0.91	136
	dog	6 mg/kg	0.023	0.0065	4.4	0.13	0.00326	8.8	0.6d	0.87	92
	human	30–450 mg	0.003	0.007	4.1	0.14	0.000623	46.3	0.3d	0.86	112
PEG/water solution (309 mg/mL)	rat	50 mg/kg	0.016	0.069	0.4	0.02	0.000818	35.3	15e	0.98	75
	dog	12 mg/kg	0.023	0.014	2.1	0.06	0.0015	19.2	7.3e	0.94	80

^aParameter definition shown in Scheme 2; k_elimination = 0.693/terminal t_1/2 from IV PK.

^bt_1/2 = 0.693/k_{direct or indirect}.

^cModel-estimated total fraction release.

^dT_lag.

^eMTT, given by MTT = (no. of transit compartments + 1)/k_tr.