. Author manuscript; available in PMC: 2024 Nov 13.

Published in final edited form as: J Chem Inf Model. 2023 Oct 17;63(21):6681–6695. doi: 10.1021/acs.jcim.3c00780

Table 4.

Cytotoxic activity in a brine shrimp model of compounds Top1 and Top2 at different concentration with LD₅₀ value.

compounds	Concentration (μg/ml)	logC	No of nauplii	dead	live	% mortality	LD50 μg/ml
Top1	25	1.3	10	1	9	10	333.3
	50	1.6	10	1	9	10
	75	1.8	10	1	9	10
	100	2	10	2	8	20

Top2	25	1.3	10	1	9	10	281
	50	1.6	10	1	9	10
	75	1.8	10	2	8	20
	100	2	10	2	8	20

Positive control (Doxorubicin)	25	1.3	10	1	9	10	187
	50	1.6	10	2	8	20
	75	1.8	10	2	8	20
	100	2	10	3	7	30
							1000
Negative control (DMSO)	25	1.397940009	10	1	9	10
	50	1.698970004	10	1	9	10
	75	1.875061263	10	1	8	20
	100	2	10	1	9	10