Table 3.
Association between GAB1 gene variants and asthma risk
| SNVs | Genotypes/ Alleles |
Asthma (n = 109) |
Control (n = 158) |
pa | OR (95%CI) | pb |
|---|---|---|---|---|---|---|
| rs1396527 | ||||||
| G/G | 47(43.1) | 85(53.8) | 0.102 | – | – | |
| G/T | 55(50.5) | 59(37.3) | 1.57(0.88–2.79) | 0.125 | ||
| T/T | 7(6.4) | 14(8.9) | 0.78(0.27–2.31) | 0.658 | ||
| G | 149(68.4) | 229(72.5) | 0.304 | – | – | |
| T | 69(31.7) | 87(27.5) | 1.41(0.81–2.45) | 0.222 | ||
| rs17017425 | ||||||
| T/T | 55(50.5) | 89(56.3) | 0.573 | – | – | |
| T/C | 47(43.1) | 58(36.7) | 1.08(0.61–1.92) | 0.782 | ||
| C/C | 7(6.4) | 11(7.0) | 1.18(0.41–3.45) | 0.760 | ||
| T | 157(72.0) | 236(74.7) | 0.492 | – | – | |
| C | 61(28.0) | 80(25.3) | 1.10(0.64–1.89) | 0.736 | ||
| rs1866756 | ||||||
| G/G | 57(52.3) | 92(58.2) | 0.287 | – | – | |
| G/A | 48(44.0) | 56(35.4) | 1.32(0.74–2.33) | 0.346 | ||
| A/A | 4(3.7) | 10(6.3) | 0.64(0.17–2.35) | 0.501 | ||
| G | 162(74.3) | 240(76.0) | 0.666 | – | – | |
| A | 56(25.7) | 76(24.1) | 1.21(0.70–2.10) | 0.503 | ||
| rs3805236 | ||||||
| A/A | 54(49.5) | 90(57.0) | 0.248 | – | – | |
| A/G | 48(44.0) | 54(34.2) | 1.42(0.79–2.54) | 0.241 | ||
| G/G | 7(6.4) | 14(8.9) | 0.85(0.30–2.43) | 0.761 | ||
| A | 156(71.6) | 234(74.1) | 0.524 | – | – | |
| G | 62(28.4) | 82(26.0) | 1.30(0.75–2.26) | 0.359 | ||
| rs3805246 | ||||||
| G/G | 58(53.2) | 92(58.2) | 0.342 | – | – | |
| G/A | 47(43.1) | 56(35.4) | 1.28(0.72–2.26) | 0.401 | ||
| A/A | 4(3.7) | 10(6.3) | 0.63(0.17–2.32) | 0.488 | ||
| G | 163(74.8) | 240(76.0) | 0.756 | – | – | |
| A | 55(25.2) | 76(24.1) | 1.17(0.68–2.04) | 0.568 | ||
| rs3805254 | ||||||
| A/A | 58(53.2) | 92(58.2) | 0.342 | – | – | |
| A/G | 47(43.1) | 56(35.4) | 1.28(0.72–2.26) | 0.401 | ||
| G/G | 4(3.7) | 10(6.3) | 0.63(0.17–2.32) | 0.488 | ||
| A | 163(74.8) | 240(76.0) | 0.756 | – | – | |
| G | 55(25.2) | 76(24.1) | 1.17(0.68–2.04) | 0.568 |
Abbreviations: OR odds ratio, CI confidence interval, a χ2 test for genotype and allele distributions between the asthma group and the control group; b binary logistic regression for genotype distributions between the asthma group and the control group, adjusted for biological sex, age, BMI, ETS exposure and residence