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. 2023 Dec 6;42:334. doi: 10.1186/s13046-023-02915-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CircGPRC5A promotes CRC cell invasion, migration, and proliferation in vitro. A CircGPRC5A overexpressions in HCT116 and SW480 were confirmed using qRT-PCR. B–G Following circGPRC5A overexpressions in SW480 and HCT116 cells, CCK-8, colony formation, and Edu assays were used to assess proliferation. H–K Transwell and wound healing assays were used to measure migration and invasion following circGPRC5A overexpressions in SW480 and HCT116 cells. Based on data from three independent experiments, values are presented as the mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001. Following transfection of MS2-CP and circGPRC5A-MS2 into CRC cells, fluorescence and bright field images were obtained