Table 3.

Genetic causal effect of potential mediators on HER-positive breast cancer

Potential mediators	Beta2	Lo_95CI	Up_95CI	P2_value
HDL cholesterol	2.85E−02	− 8.63E−02	1.43E−01	6.27E−01
LDL cholesterol	6.97E−02	− 5.83E−02	1.98E−01	2.86E−01
SHBG	− 8.30E−02	− 3.50E−01	1.84E−01	5.42E−01
Total testosterone	4.06E−01	5.62E−02	7.56E−01	2.29E−02*
Bioavailable testosterone	1.73E−01	3.61E−02	3.81E−01	1.05E−01
Estradiol levels	1.34E+00	− 6.24E−01	3.30E+00	1.82E−01
Fasting glucose	− 1.66E−01	− 4.72E−01	1.39E−01	2.86E−01

All the results above were derived from the IVW method.

*P2_value < 0.05; Lo_95CI, the lower margin of beta 2’s 95% confidence interval; Up_95CI, the upper margin of beta 2’s 95% confidence interval; SHBG, Sex hormone-binding globulin; HDL, high-density lipoprotein; LDL, low-density lipoprotein