. 2023 Nov 10;15:1251075. doi: 10.3389/fnagi.2023.1251075

Table 1.

Summary of LDT effects in 3xTg-AD mouse model.

Difference between WT and Tg	Age (months)	Sex	Behavior	Effect sizes/significance (η², d, p)	Authors
✓	4, 8	M	WT spent more time in the dark compartment compared to Tg.	η² = 0.22 (Time in compartment)	Várkonyi et al. (2022)
✓	4, 8	M	Motivation to explore decreased significantly in 8 mo. Tg animals.	η² = 0.09 (Motivation)	Várkonyi et al. (2022)
✓	6	M, F	White box entries and time spent in light significantly decreased for Tg	p < 0.05	Zhang Y. L. et al. (2016)
✓	6	M, F		p < 0.05	Zhang Y. L. et al. (2016)
✓	12	M, F	Tg mice spent less time on the white side; this effect is more pronounced in Tg M.	η² = 0.12 (Tg, M and F)	Blázquez et al. (2014)
✓	12	M, F		η² = 0.09 (Tg, M)	Blázquez et al. (2014)