Table 2.
Summary of EPM effects in 3xTg-AD mouse model.
| Difference between WT and Tg | Age (months) | Sex | Behavior | Effect sizes/significance (η2, d, p) | Authors |
|---|---|---|---|---|---|
| ✘ | 3, 9, 12 | M | No differences between WT and Tg | NR | Pairojana et al. (2021) |
| ✓ | 3, 6, 9 | F | Tg spent more time in the open arms and less time in the closed arms. | η2 = 0.46 (3mo. Open arm) | Pairojana et al. (2021) |
| η2 = 0.42 (3mo. Closed arm) | |||||
| η2 = 0.26 (6 mo. Open arm) | |||||
| η2 = 0.30 (9 mo. Open arm) | |||||
| ✘ | 4, 8 | M | No differences between WT and Tg in open arm time or locomotion | η2 = 0.01 (Open arm time) | Várkonyi et al. (2022) |
| *η2 = 0.07 (Locomotion) | |||||
| ✘ | 6 | M, F | No differences between WT and Tg in distance traveled or locomotor activity | η2 = 0 (Distance traveled) | Hebda-Bauer et al. (2013) |
| η2 = 0 (Locomotion) | |||||
| ✓ | 6 | M | Tg spent decreased time in the closed arms | d = 2.99 | Pairojana et al. (2021) |
| ✓ | 6 | M, F | Tg animals had more entries in the closed arms. Tg animals spent less time in the open arms. | p = 0.006 (Closed arm entries) | Zhang C. et al. (2016) |
| p = 0.004 (Open arm time) | |||||
| ✘ | 7.5–11 | F | No significant differences between WT and Tg | η2 = 0.03 | Sterniczuk et al. (2010) |
| ✘ | 12 | F | No differences between WT and Tg | NR | Pairojana et al. (2021) |