Table 4.
Summary of OFT effects in 3xTg-AD mouse model.
| Difference between WT and Tg | Age (months) | Sex | Behavior | Effect sizes/significance (η2, d, p) | Authors |
|---|---|---|---|---|---|
| ✓ | 3, 12 | M, F | Tg had significantly decreased locomotion. | η2 = 0.31 (3 mo.) | Pairojana et al. (2021) |
| ✘ | 6 | No significant differences in locomotion. | η2 = 0.55 (12 mo.) | ||
| ✓ | 9 | M Tg had significantly decreased speed and locomotion compared to Tg F and WT. | NR (6 mo.) | ||
| d = 6.67 (9 mo., Speed) | |||||
| d = 14.89 (9 mo., Locomotion) | |||||
| ✓ | 4, 8 | M | Tg spent less time in active movement. | η2 = 0.36 (4 mo.) | Várkonyi et al. (2022) |
| η2 = 0.29 (8 mo.) | |||||
| ✘ | 6 | No difference in total distance traveled between Tg and WT. | p > 0.05 (Distance) | Zhang C. et al. (2016) | |
| ✓ | WT spent more time in center. | p < 0.05 (Center) | |||
| ✘ | 6 | M, F | No differences in locomotor activity between Tg and WT. | η2 = 0.04 (Locomotion) | Hebda-Bauer et al. (2013) |
| ✓ | Tg spent more time in the center. | η2 = 0.21 (Center) | |||
| ✘ | 7.5–11 | F | No significant differences in locomotion between Tg and WT. | *η2 = 0.39 (Distance) | Sterniczuk et al. (2010) |
| ✓ | Tg spent more time in the center compared to WT. | *η2 = 0.50 (Speed) | |||
| η2 = 0.11 (Center) | |||||
| ✓ | 12, 15 | M, F | Tg exhibit less exploratory behavior (12 mo.). | η2 = 0.19 (12 mo.) | Blázquez et al. (2014) |
| Tg mice exhibit more freezing behavior (15 mo.). | η2 = 0.24 (15 mo.) | ||||
| ✓ | 12 | M | Grooming behaviors appeared later in the task. | d = 1.38 | Torres-Lista et al. (2015) |