Table 6.
Summary of OFT effects in TgF344-AD rat model.
| Difference between WT and Tg | Age (months) | Sex | Behavior | Effect sizes/significance (η2, d, p) | Authors |
|---|---|---|---|---|---|
| ✘ | 2, 12 | M | No differences between Tg and WT (2 mo.) | NR (2 mo.) | Wu et al. (2020) |
| ✓ | Tg rats spent less time in the center (12 mo.) | p < 0.01 (12 mo.) | |||
| ✓ | 6, 12 | M, F | 12 mo. Tg animals moved less compared to 6 mo. Tg animals. | η2 = 0.17 (Locomotion) | Kelberman et al. (2022) |
| ✓ | Tg animals spent less time in the center (6 mo., 12 mo.) | η2 = 0.06 (Center Time) | |||
| ✘ | 6, 15 | M, F | No difference between Tg and WT (6 mo.) | p > 0.05 (6 mo.) | Cohen et al. (2013) |
| ✓ | Tg reared significantly more. (15 mo.) | p < 0.05 (15 mo.) | |||
| ✘ | 6, 12, 18 | M, F | No differences between Tg and WT (M). | η2 < 0.03 (M, 6, 12, 18 mo.) | Saré et al. (2020) |
| ✓ | Female Tg hypoactivity (6 and 12 mo.) | η2 < 0.03 (F, 6, 12 mo.) | |||
| ✘ | No significant differences between Tg and WT females (18 mo.) | ||||
| ✓ | 9, 12 | M, F | Tg F spent less time in center compared to M Tg and WT (9 mo.). | p < 0.05 (9 mo.) | Srivastava et al. (2023) |
| ✘ | No significant differences between Tg and WT (12 mo.). | NR (12 mo.) |