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Effect of domiphen and itraconazole on intracellular drug retention and biofilm of Aspergillus fumigatus. (A) Extracellular itraconazole content in A. fumigatus cells treated with itraconazole before and after domiphen treatment indicated as Itz and I+D, respectively. *p < 0.05; **p < 0.01 according to unpaired two-tailed t-test. (B) Biofilm clearance efficiency of domiphen, itraconazole, and domiphen combined with itraconazole against four A. fumigatus strains.
