Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 14;133(12):1040–1055. doi: 10.1161/CIRCRESAHA.123.323571

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

PMC Copyright notice

Figure 8. — Pretreatment with S-nitrosoglutathione (GSNO) prevents ISO-induced arrhythmias in Langendorff-perfused hearts from wild-type (WT), but not CaMKIIδ (Ca²⁺/calmodulin kinase II delta)-C273S, mice. Arrhythmias were measured in Langendorff-perfused hearts following protocols outlined in Figure 7A. A, Examples of arrhythmic events observed in the isolated hearts. We measured (B) quantity of arrhythmic events and (C) arrhythmia score during ISO perfusion only, (D) quantity of arrhythmic events and (E) arrhythmia score during ISO pretreatment before GSNO, and (F) quantity of arrhythmic events and (G) arrhythmia score during GSNO pretreatment before ISO. White bar=buffer, red bar=ISO, blue bar=GSNO. n=5 to 6 hearts per group. ISO indicates isoproterenol.