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. 2023 Sep 18;78(12):2045–2059. doi: 10.1093/geronb/gbad128

Figure 1.

Figure 1.

Multicategorical Mediation Model. Loneliness trajectory groups 1, 2, … , j refer to the different loneliness trajectory classes found in the Growth Mixture Models. DNAm AgeAccel2016 refers to Horvath Age Acceleration, Hannum Age Acceleration, Horvath (skin) Age Acceleration, DNAm PhenoAge Acceleration, GrimAge Acceleration, and Dunedin PoAm38 Acceleration. CF2016 refers to TICSm, immediate memory recall, delayed memory recall, and processing speed. Covariates include cohort, sex, race/ethnicity, APOE ε4 status, social isolation, current smoking status, depressive symptomatology, self-rated health, and BMI. The parameters a1, a2, … , aj−1, refer to the effect of each loneliness trajectory group on DNAm AgeAccel for j–1 groups (the largest latent class group was selected as the reference group). The parameter b refers to the direct effect of DNAm AgeAccel measure on the cognitive functioning outcome. The parameters c’1, c’2, … , c’j−1, refer to the adjusted direct effect of each loneliness trajectory group for j–1 groups on the cognitive outcome.