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. 2023 Sep 18;78(12):2045–2059. doi: 10.1093/geronb/gbad128

Table 4.

Multicategorical Mediation Parameter Estimates, Indirect and Total Effects

Parameters Horvath Accel HorvathSkin Accel
Baseline Full Baseline Full
Est. .95 CI Est. .95 CI Est. .95 CI Est. .95 CI
Total effects of loneliness trajectories
Low → TICS2016 −0.655 [−1.186, −0.148] −0.062 [−0.514, 0.367] −0.655 [−1.186, −0.147] −0.062 [−0.515, 0.366]
Moderate → TICS2016 −1.119 [−1.717, −0.486] −0.447 [−1.014, 0.121] −1.119 [−1.717, −0.485] −0.448 [−1.012, 0.121]
Moderate-But-Declining → TICS2016 −1.341 [−1.880, −0.794] −0.209 [−0.733, 0.318] −1.341 [−1.879, −0.794] −0.211 [−0.734, 0.317]
High-But-Declining → TICS2016 −1.643 [−2.345, −0.956] −0.403 [−1.106, 0.287] −1.643 [−2.344, −0.955] −0.409 [−1.112, 0.282]
Indirect effects
Low → DNAm AgeAccel2016 → TICS2016 0.002 [−0.017, 0.024] 0.006 [−0.008, 0.030] −0.008 [−0.035, 0.011] 0.001 [−0.012, 0.020]
Moderate → DNAm AgeAccel2016 → TICS2016 0.000 [−0.015, 0.014] −0.001 [−0.018, 0.015] −0.003 [−0.031, 0.021] 0.000 [−0.013, 0.015]
Moderate-But-Declining → DNAm AgeAccel2016 → TICS2016 0.002 [−0.023, 0.030] 0.008 [−0.010, 0.036] −0.025 [−0.070, 0.012] 0.003 [−0.029, 0.040]
High-But-Declining → DNAm AgeAccel2016 → TICS2016 0.001 [−0.021, 0.028] 0.004 [−0.016, 0.035] −0.019 [−0.074, 0.014] 0.002 [−0.026, 0.039]
Adjusted direct effects of loneliness trajectories
Low → TICS2016 −0.657 [−1.191, −0.146] −0.067 [−0.519, 0.359] −0.647 [−1.183, −0.142] −0.063 [−0.516, 0.367]
Moderate → TICS2016 −1.119 [−1.718, −0.493] −0.445 [−1.014, 0.120] −1.117 [−1.719, −0.482] −0.449 [−1.007, 0.114]
Moderate-But-Declining → TICS2016 −1.343 [−1.881, −0.793] −0.217 [−0.745, 0.309] −1.317 [−1.842, −0.776] −0.214 [−0.744, 0.305]
High-But-Declining → TICS2016 −1.644 [−2.350, −0.954] −0.408 [−0.745, 0.309] −1.624 [−2.325, −0.939] −0.412 [−1.116, 0.271]
Effect of DNAm AgeAccel2016 on TICS2016
DNAm AgeAccel2016 → TICS2016 0.003 [−0.026, 0.032] 0.012 [−0.013, 0.036] −0.031 [−0.077, 0.013] 0.004 [−0.034, 0.042]
Effects of Loneliness on DNAm AgeAccel2016
Low → DNAm AgeAccel2016 0.483 [−0.301, 1.296] 0.483 [−0.301, 1.296] 0.257 [−0.272, 0.799] 0.257 [−0.272, 0.799]
Moderate → DNAm AgeAccel2016 −0.121 [−0.970, 0.783] −0.121 [−0.970, 0.783] 0.086 [−0.527, 0.684] 0.086 [−0.527, 0.684]
Moderate-But-Declining → DNAm AgeAccel2016 0.636 [−0.271, 1.591] 0.636 [−0.271, 1.591] 0.800 [0.235, 1.374] 0.800 [0.235, 1.374]
High-But-Declining → DNAm AgeAccel2016 0.342 [−0.915, 1.529] 0.342 [−0.915, 1.529] 0.616 [−0.238, 1.511] 0.616 [−0.238, 1.511]
Parameters Hannum Accel DNAm PhenoAge Accel
Baseline Full Baseline Full
Est. .95 CI Est. .95 CI Est. .95 CI Est. .95 CI
Total effects of loneliness trajectories
Low → TICS2016 −0.655 [−1.186, −0.147] −0.067 [−0.519, 0.366] −0.655 [−1.186, −0.147] −0.068 [−0.520, 0.361]
Moderate → TICS2016 −1.120 [−1.717, −0.487] −0.453 [−1.012, 0.125] −1.120 [−1.718, −0.486] −0.455 [−1.014, 0.116]
Moderate-But-Declining → TICS2016 −1.342 [−1.880, −0.794] −0.215 [−0.744, 0.312] −1.341 [−1.881, −0.793] −0.222 [−0.750, 0.308]
High-But-Declining → TICS2016 −1.644 [−2.345, −0.956] −0.415 [−1.115, 0.279] −1.643 [−2.389, −0.897] −0.418 [−1.124, 0.266]
Indirect effects
Low → DNAm AgeAccel2016 → TICS2016 0.003 [−0.016, 0.025] 0.001 [−0.012, 0.016] −0.043 [−0.102, 0.002] −0.010 [−0.031, 0.011]
Moderate → DNAm AgeAccel2016 → TICS2016 0.008 [−0.013, 0.038] 0.002 [−0.014, 0.024] −0.023 [−0.080, 0.025] −0.005 [−0.031, 0.011]
Moderate-But-Declining → DNAm AgeAccel2016 → TICS2016 −0.013 [−0.053, 0.010] −0.004 [−0.034, 0.019] −0.065 [−0.133, −0.013] −0.016 [−0.055, 0.015]
High-But-Declining → DNAm AgeAccel2016 → TICS2016 −0.016 [−0.070, 0.014] −0.005 [−0.042, 0.024] −0.066 [−0.154, 0.004] −0.016 [−0.066, 0.016]
Adjusted direct effects of loneliness trajectories
Low → TICS2016 −0.658 [−1.190, −0.151] −0.068 [−0.524, 0.362] −0.612 [−1.140, −0.116] −0.058 [−0.511, 0.366]
Moderate → TICS2016 −1.127 [−1.719, −0.498] −0.455 [−1.013, 0.119] −1.097 [−1.699, −0.457] −0.450 [−1.011, 0.112]
Moderate-But-Declining → TICS2016 −1.329 [−1.866, −0.781] −0.211 [−0.735, 0.311] −1.276 [−1.809, −0.727] −0.206 [−0.739, 0.325]
High-But-Declining → TICS2016 −1.628 [−2.329, −0.942] −0.410 [−1.114, 0.268] −1.577 [−2.281, −0.886] −0.402 [−1.108, 0.277]
Effect of DNAm AgeAccel2016 on TICS2016
DNAm AgeAccel2016 → TICS2016 −0.020 [−0.058, 0.014] −0.006 [−0.039, 0.025] −0.051 [−0.079, −0.023] −0.012 [−0.038, 0.012]
Effects of loneliness on DNAm AgeAccel2016
Low → DNAm AgeAccel2016 −0.148 [−0.814, 0.520] −0.148 [−0.814, 0.520] 0.849 [−0.041, 1.689] 0.849 [−0.041, 1.689]
Moderate → DNAm AgeAccel2016 −0.392 [−1.138, 0.340] −0.392 [−1.138, 0.340] 0.444 [−0.521, 1.382] 0.444 [−0.521, 1.382]
Moderate-But-Declining → DNAm AgeAccel2016 0.617 [−0.091, 1.331] 0.617 [−0.091, 1.331] 1.278 [0.333, 2.197] 1.278 [0.333, 2.197]
High-But-Declining → DNAm AgeAccel2016 0.791 [−0.210, 1.782] 0.791 [−0.210, 1.782] 1.293 [−0.097, 2.594] 1.293 [−0.097, 2.594]
Parameters GrimAge Accel Dunedin PoAm 38 Accel
Baseline Full Baseline Full
Est. .95 CI Est. .95 CI Est. .95 CI Est. .95 CI
Total effects of loneliness trajectories
Low → TICS2016 −0.655 [−1.186, −0.149] −0.096 [−0.552, 0.340] −0.655 [−1.186, −0.144] −0.076 [−0.531, 0.360]
Moderate → TICS2016 −1.122 [−1.721, −0.486] −0.486 [−1.050, 0.090] −1.120 [−1.719, −0.485] −0.458 [−1.018, 0.114]
Moderate-But-Declining → TICS2016 −1.341 [−1.879, −0.794] −0.269 [−0.800, 0.269] −1.340 [−1.880, −0.790] −0.229 [−0.757, 0.299]
High-But-Declining → TICS2016 −1.643 [−2.346, −0.950] −0.477 [−1.180, 0.229] −1.641 [−2.345, −0.950] −0.435 [−1.144, 0.256]
Indirect effects
Low → DNAm AgeAccel2016 → TICS2016 −0.099 [−0.187, −0.011] −0.032 [−0.084, 0.000] −0.025 [−0.082, 0.029] −0.004 [−0.028, 0.013]
Moderate → DNAm AgeAccel2016 → TICS2016 −0.070 [−0.178, 0.033] −0.023 [−0.072, 0.011] −0.016 [−0.086, 0.052] −0.003 [−0.027, 0.017]
Moderate-But-Declining → DNAm AgeAccel2016 → TICS2016 −0.174 [−0.289, −0.073] −0.057 [−0.134, −0.005] −0.101 [−0.183, −0.037] −0.017 [−0.073, 0.027]
High-But-Declining → DNAm AgeAccel2016 → TICS2016 −0.175 [−0.344, −0.019] −0.057 [−0.147, 0.000] −0.022 [−0.117, 0.070] −0.004 [−0.037, 0.021]
Adjusted direct effects of loneliness trajectories
Low → TICS2016 −0.557 [−1.084, −0.061] −0.064 [−0.520, 0.367] −0.630 [−1.157, −0.119] −0.071 [−0.527, 0.359]
Moderate → TICS2016 −1.052 [−1.640, −0.436] −0.463 [−1.033, 0.103] −1.103 [−1.698, −0.477] −0.455 [−1.018, 0.113]
Moderate-But-Declining → TICS2016 −1.166 [−1.668, −0.623] −0.212 [−0.734, 0.320] −1.239 [−1.772, −0.698] −0.212 [−0.737, 0.311]
High-But-Declining → TICS2016 −1.467 [−2.165, −0.770] −0.420 [−1.135, 0.265] −1.619 [−2.327, −0.943] −0.432 [−1.143, 0.252]
Effect of DNAm AgeAccel2016 on TICS2016
DNAm AgeAccel2016 → TICS2016 −0.156 [−0.196, −0.119] −0.051 [−0.099, −0.006] −4.891 [−6.979, −2.918] −0.839 [−3.082, 1.353]
Effects of loneliness on DNAm AgeAccel2016
Low → DNAm AgeAccel2016 0.633 [0.071, 1.179] 0.633 [0.071, 1.179] 0.005 [−0.007, 0.016] 0.005 [−0.007, 0.016]
Moderate → DNAm AgeAccel2016 0.447 [−0.215, 1.102] 0.447 [−0.215, 1.102] 0.003 [−0.011, 0.017] 0.003 [−0.011, 0.017]
Moderate-But-Declining → DNAm AgeAccel2016 1.116 [0.473, 1.707] 1.116 [0.473, 1.707] 0.021 [0.008, 0.033] 0.021 [0.008, 0.033]
High-But-Declining → DNAm AgeAccel2016 1.124 [0.111, 2.115] 1.124 [0.111, 2.115] 0.005 [−0.014, 0.022] 0.005 [−0.014, 0.022]

Note: Estimates are unstandardized. Bolded values are statistically significant at the .05 level.