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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Nature. 2023 Sep 20;622(7983):507–513. doi: 10.1038/s41586-023-06535-1

Extended Data Fig. 1 ∣. Portimine A (PA) inhibits the growth of human and mouse cell lines in the low nanomolar range.

Extended Data Fig. 1 ∣

Concentration–response curves for PA and IC50 (95% IC) values in human (a-q) and mouse (r-t) cell lines: a) Jurkat (leukemia). b) RD (rhabdomyosarcoma). c) HT-1080 (fibrosarcoma). d) A673 (Ewings sarcoma). e) HCC1806 (acantholytic squamous cell carcinoma). f) HeLa (cervical adenocarcinoma). gx) MCF-7 (breast adenocarcinoma). h) MDA-MB-231 (breast adenocarcinoma). i) SUM159 (breast adenocarcinoma). j) HepG2 (hepatocellular carcinoma). k) LNCaP (prostate carcinoma). l) 786-O (renal adenocarcinoma). m) GBM-A (glioblastoma). n) GBM-F (glioblastoma). o) LN229 (glioblastoma). p) U87EGFRvIII (glioblastoma). q) U118 (glioblastoma). r) MC38 (colon carcinoma). s) B16-F10 (melanoma). t) 4T1 (mammary carcinoma). Cells were treated with PA at different concentrations for 72 h, followed by the CellTiter-Glo proliferation assay. Data represents mean ± s.d. of three biologically replicated experiments.