Table 1.

Differential Immune Gene Sets Between MRI Phenotypes for All Tissues

Gd+ vs. Gd–	FLAIR+ vs. FLAIR–	Fe+ vs. Fe–
Interferon-gamma response	Interferon-gamma response*	Interferon-gamma response*
Interferon-alpha response	Interferon-alpha response*	Interferon-alpha response*
IL6 STAT3 signaling during acute phase response	IL6 STAT3 signaling during acute phase response	Allograft rejection*
Blood coagulation cascade	Inflammation	IL6 STAT3 signaling during acute phase response
Inflammation	Allograft rejection	Inflammation*
Complement cascade	Blood coagulation cascade	Complement cascade*
Allograft rejection		Blood coagulation cascade

^* Highly enriched gene set with NES of at least 2.5. Note: Gene sets are listed in decreasing NES.