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. Author manuscript; available in PMC: 2023 Dec 6.
Published in final edited form as: Annu Rev Biophys. 2022 Jan 4;51:157–179. doi: 10.1146/annurev-biophys-092721-085421

Figure 5.

Figure 5

All-against-all orthogonality of 16 pairs of heterodimers assessed by online ion exchange chromatography coupled with native mass spectrometry. Red boxes indicate designed cognate pairs. Exchange of unlabeled and partially 15N-labeled DHD37_ABXB results in a distribution of overlapping species. Figure adapted with permission from Reference 23; copyright 2018 Springer Nature Limited. Abbreviations: AmAc, ammonium acetate; TBS, Tris-buffered saline.