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. 2023 Dec 6;624(7990):164–172. doi: 10.1038/s41586-023-06802-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, FIBA was applied to all aging models to assess peripheral versus central contributions to brain aging and cognitive decline (CDR-Global dementia rating). For each aging model, proteins were assessed for their contributions to the age gap association with cognition (CDR-Global, y-axis) and chronological age prediction accuracy (x-axis). Proteins for which permutation reduces the age gap association with cognition were termed FIBA+ , while proteins for which permutation strengthens the age gap association with dementia were termed FIBA-. FIBA+ proteins were used to train new cognition-optimized aging models from healthy individuals in the Knight-ADRC cohort. FIBA results for all aging models are shown in alphabetical order. (See ST15).