Fig. 5.

The effect of miR-135a mimics and inhibitors on HTR-8/SVneo cells.

A The banding between HOXD-AS1 and miR-135a, miR-135a and β-TRCP 3′UTR was evaluated by dual luciferase reporter assay. B The effect of miR-135a mimics and inhibitors on the RNA level of HOXD-AS1, miR-135a and β-TRCP in HTR-8/SVneo cells. C The protein level of β-TRCP and NF-κB pathway. D Cell activity. E The level of 2 inflammatory factors in the supernatant of HTR-8/SVneo cells. F Cell apoptosis. G Cell invasion. H Cell migration. NC: nagtive control. *p < 0.05, ***p < 0.001, vs. mimics NC group; ##p < 0.01, ###p < 0.001, vs. inhibitor NC group.