Skip to main content
. 2023 Dec 6;14:8069. doi: 10.1038/s41467-023-43848-1

Fig. 1. CAR peptide accelerates wound closure.

Fig. 1

Mice with full thickness skin excision wounds were treated i.v. twice a day with CAR, mCAR or control (BSA/PBS) injections from day one post-wounding until the sacrifice as described in methods. Wounds were examined and photographed daily. Wound closure was recorded and expressed (a, b) as the percentage of the open wound size relative to its original size on the day of wounding (Day 7: CAR vs. Control P = 0.0041, CAR vs. mCAR P = 2.0 × 10−06; Day 8: CAR vs. Control P = 0.009, CAR vs. mCAR P = 9.5 × 10−08; Day 9: CAR vs. Control P = 0.00027, CAR vs. mCAR P = 1.3 × 10−06; Day 10: CAR vs. Control P = 0.001, CAR vs. mCAR P = 1.6 × 10−06) or (c) as the percentage of the number of completely closed wounds (Day 8: CAR vs. Control P = 0.078 (not significant), CAR vs. mCAR P = 0.017; Day 9: CAR vs. Control P = 0.0049, CAR vs. mCAR P = 0.0003; Day 10: CAR vs. Control P = 0.0064, CAR vs. mCAR P = 0.0001). d Representative macroscopic digital pictures of the wounds treated with CAR, mCAR and control peptide injections are shown at different time-points of the wound closure process. There were 24 animals, each with four wounds, in every treatment group. Source data are provided as a Source Data file. Values are mean ± S.E.M. Each data point represents an individual wound. n = 96 (Days 0–5), 60 (Days 6–7) and 32 (Days 8–10) wounds in each treatment group. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. Krustal-Wallis rank sum test with Dunn´s test with tie correction (a, b) and Pearson´s Chi-square test (without continuity correction) with post-hoc test Fisher exact test (two-sided) (c).