Table 2.

Detailed histopathological score of the examined organs from all animals. The total score for each animal was the number used in the statistic evaluation. The weight difference for all animals between administration and sacrifice days is listed. As all values are equal or above zero, no animal has lost weight. Explanation of animals coding: C, control; NPC, PLGA NPs with chitosan, with curcumin; NPP, PLGA NPs without chitosan, with curcumin; A, group sacrificed 1 day after administration; B, group sacrificed 1 week after administration. 1 to 8: animal number

Code	Sex	Animal weight difference in grams, between day of administration and day of sacrifice	Brain	Heart	Liver	Kidney	Lung	Stomach	Skin	Total score for all organs	Comments
CA1	Male	5	0	0	0	0	0	0	0	0
CA2	Female	0	0	0	0	0	0	0	0	0
NPPA1	Male	0	0	0	1	0	0	0	0	1
NPPA2	Male	2	0	0	0	0	0	0	1	1
NPPA3	Male	4	0	0	0	0	0	0	0	0
NPPA4	Male	5	0	0	0	0	0	0	0	0
NPPA5	Female	0	2	0	0	0	0	0	0	2
NPPA6	Female	0	0	0	0	0	0	0	0	0
NPPA7	Female	0	0	0	0	0	0	0	0	0
NPPA8	Female	0	2	0	0	0	0	0	1	3
NPCA1	Male	4	0	0	0	0	0	0	0	0
NPCA2	Male	0	0	0	0	0	0	0	0	0
NPCA3	Male	0	0	0	0	0	0	0	0	0
NPCA4	Male	3	0	0	0	0	0	0	0	0
NPCA5	Female	0	0	0	0	0	0	0	0	0
NPCA6	Female	2	0	0	0	0	0	0	0	0
NPCA7	Female	0	0	0	0	0	0	0	0	0
NPCA8	Female	2	0	0	0	0	0	0	0	0
CB1	Male	8	0	0	0	0	0	0	0	0
CB2	Female	6	0	0	0	0	0	0	0	0
NPPB1	Male	5	0	0	0	0	0	0	0	0
NPPB2	Male	6	2	0	0	0	0	0	1	3
NPPB3	Male	8	3	0	0	1	0	0	0	4
NPPB4	Male	3	3	0	0	0	0	0	2	5	Cerebellum: calcifications
NPPB5	Female	4	3	0	0	0	0	0	0	3
NPPB6	Female	5	3	0	1	0	0	0	2	6
NPPB7	Female	3	0	0	0	0	0	0	1	1
NPPB8	Female	5	4	0	0	0	0	0	1	5	Brain: two small areas with neurophagia; mild increase of inflammatory cells incl. rare neutrophils
NPCB1	Male	6	0	0	0	0	0	0	0	0
NPCB2	Male	4	0	0	0	0	0	0	0	0
NPCB3	Male	2	2	0	0	0	0	0	0	2
NPCB4	Male	9	0	0	0	0	0	0	0	0
NPCB5	Female	5	0	0	0	0	0	0	1	1
NPCB6	Female	11	0	0	0	0	0	0	0	0
NPCB7	Female	9	0	0	0	0	0	0	0	0
NPCB8	Female	5	0	0	1	0	0	0	0	1