Fig. 3.

CDIM/NR4A1 antagonists inhibit colon tumor growth in a syngeneic mouse model. C57BL/6 mice bearing MC-38 cells as xenografts were treated for 21 days with corn oil (control), DIM-3-Br-5-OCF₃ (2.5 and 7.5 mg/kg/d), DIM-3,5-Cl₂ (2.5 and 7.5 mg/kg/d) and effects on tumor volume (A, B), body weight changes (C) and tumor weights (D) were determined as outlined in Methods. E. Tumor lysates from three animals per treatment group were analyzed by western blot as outlined in Methods. The Results are expressed as means ± SD. n = 6 mice/group. Significant (p values) induction or inhibition is indicated in graphs