Table 3.
Univariate and multivariable interval censored proportional hazards model regression estimates of relative risk of being confirmed negative for ZIKV in urine.
| Selected baseline factors | Univariate model | Multivariable model | ||
|---|---|---|---|---|
| Univariate HR (95% CI) | Chi-sq p value | Adjusted HR (95% CI) | Chi-sq p value | |
| Sex | – | – | ||
| Male | 1.00 | 1.00 | ||
| Female | 1.48 (1.12, 1.96) | 0.0063 | 1.47 (1.11, 1.95) | 0.0073 |
| Age group | ||||
| ≤ 35 | 1.00 | 1.00 | ||
| > 35 | 0.75 (0.58, 0.98) | 0.031 | 0.76 (0.59, 0.98) | 0.037 |
| Education Level | – | – | ||
| Secondary or lower | 1.00 | |||
| Post-secondary | 0.88 (0.66, 1.16) | 0.36 | ||
| BMI category (kg/m2) | – | – | ||
| Normal weight (18.5–24.99) | 1.00 | |||
| Overweight or obese (≥ 25.0) | 0.74 (0.56, 0.98) | 0.038 | ||
| Household members (excluding self) | – | – | ||
| < 3 | 1.00 | |||
| ≥ 3 | 0.87 (0.66, 1.15) | 0.32 | ||
| Fever today or past 30 days | – | – | ||
| (Yes vs No) | 0.91 (0.65, 1.29) | 0.61 | ||
| Rash today or past 30 days | – | – | ||
| (Yes vs No) | 1.52 (0.48, 4.86) | 0.48 | ||
| Pruritus today or past 30 days | – | – | ||
| (Yes vs No) | 0.97 (0.57, 1.65) | 0.90 | ||
| Non purulent conjunctivitis today or past 30 days | – | – | ||
| (Yes vs No) | 1.05 (0.79, 1.40) | 0.74 | ||
| Joint pain today or past 30 days | – | – | ||
| (Yes vs No) | 1.07 (0.77, 1.48) | 0.71 | ||
| Periarticular edema today or past 30 days | – | – | ||
| (Yes vs No) | 1.06 (0.81, 1.40) | 0.67 | ||
| Yellow fever vaccination? | – | – | ||
| (Yes vs No) | 0.83 (0.51, 1.36) | 0.46 | ||
HR > 1 implies a higher probability of being confirmed ZIKV RNA negative in urine (lower likelihood of ZIKV persistence); HR < 1 implies a lower probability of being confirmed ZIKV RNA negative in urine (increased likelihood of ZIKV persistence).
ZIKV Zika virus, BMI body mass index, HR hazard ratio, CI confidence interval.