Table 4.
Univariate and multivariable interval censored proportional hazards model regression estimates of relative risk of being confirmed negative for ZIKV in saliva.
| Selected baseline factors | Univariate model | Multivariable model | ||
|---|---|---|---|---|
| Univariate HR (95% CI) | Chi-sq p value | Adjusted HR (95% CI) | Chi-sq p value | |
| Sex | – | – | ||
| Male | 1.00 | 1.00 | ||
| Female | 1.29 (0.98, 1.71) | 0.073 | 1.29 (0.98, 1.71) | 0.073 |
| Age group | – | – | ||
| ≤ 35 | 1.00 | |||
| > 35 | 0.93 (0.72, 1.20) | 0.57 | ||
| Education level | – | – | ||
| Secondary or lower | 1.00 | |||
| Post-secondary | 0.88 (0.67, 1.17) | 0.38 | ||
| BMI category (kg/m2) | – | – | ||
| Normal weight (18.5–24.99) | 1.00 | |||
| Overweight or obese (≥ 25.0) | 1.01 (0.77, 1.34) | 0.94 | ||
| Household members (excluding self) | – | – | ||
| < 3 | 1.00 | |||
| ≥ 3 | 0.88 (0.66, 1.17) | 0.37 | ||
| Fever today or past 30 days | – | – | ||
| (Yes vs No) | 1.06 (0.75, 1.50) | 0.76 | ||
| Rash today or past 30 days | – | – | ||
| (Yes vs No) | 3.0 (0.95, 9.52) | 0.06 | ||
| Pruritus today or past 30 days | – | – | ||
| (Yes vs No) | 1.27 (0.74, 2.20) | 0.38 | ||
| Non purulent conjunctivitis today or past 30 days | – | – | ||
| (Yes vs No) | 1.26 (0.94, 1.69) | 0.13 | ||
| Joint pain today or past 30 days | – | – | ||
| (Yes vs No) | 1.25 (0.90, 1.73) | 0.19 | ||
| Periarticular edema today or past 30 days | – | – | ||
| (Yes vs No) | 1.04 (0.79, 1.38) | 0.76 | ||
| Yellow fever vaccination? | – | – | ||
| (Yes vs No) | 1.03 (0.63, 1.69) | 0.91 | ||
HR > 1 implies a higher probability of being confirmed ZIKV RNA negative in saliva (lower likelihood of ZIKV persistence); HR < 1 implies a lower probability of being confirmed ZIKV RNA negative in saliva (increased likelihood of ZIKV persistence).
ZIKV Zika virus, BMI body mass index, HR hazard ratio, CI confidence interval.