Table 7.
Univariate and multivariable interval censored proportional hazards model regression estimates of relative risk of being confirmed negative for ZIKV in vaginal secretions.
| Selected baseline factors | Univariate model | Multivariable model | ||
|---|---|---|---|---|
| Univariate HR (95% CI) | Chi-sq p value | Adjusted HR (95% CI) | Chi-sq p value | |
| Age group | – | – | ||
| ≤ 35 | 1.00 | |||
| > 35 | 1.01 (0.74, 1.36) | 0.97 | ||
| Education level | – | – | ||
| Secondary or lower | 1.00 | |||
| Post-secondary | 1.05 (0.76, 1.45) | 0.78 | ||
| BMI category (kg/m2) | ||||
| Normal weight (18.5–24.99) | 1.00 | 1.00 | ||
| Overweight or obese (≥ 25.0) | 0.75 (0.54, 1.05) | 0.09 | 0.67 (0.48, 0.95) | 0.026 |
| Household members (excluding self) | – | – | ||
| < 3 | 1.00 | |||
| ≥ 3 | 0.87 (0.63, 1.21) | 0.40 | ||
| Fever today or past 30 days | – | – | ||
| (Yes vs No) | 0.85 (0.58, 1.24) | 0.39 | ||
| Rash today or past 30 days* | – | – | ||
| (Yes vs No) | 1.79 (0.24, 13.4) | 0.57 | ||
| Pruritus today or past 30 days | – | – | ||
| (Yes vs No) | 0.71 (0.34, 1.49) | 0.37 | ||
| Non purulent conjunctivitis today or past 30 days | ||||
| (Yes vs No) | 1.29 (0.92, 1.80) | 0.14 | 1.46 (1.02, 2.10) | 0.04 |
| Joint pain today or past 30 days | – | – | ||
| (Yes vs No) | 1.38 (0.90, 2.10) | 0.14 | ||
| Periarticular edema today or past 30 days | – | – | ||
| (Yes vs No) | 0.80 (0.55, 1.16) | 0.24 | ||
| Yellow fever vaccination? | – | – | ||
| (Yes vs No) | 1.02 (0.57, 1.82) | 0.96 | ||
HR > 1 implies a higher probability of being confirmed ZIKV RNA negative in vaginal secretions (lower likelihood of ZIKV persistence); HR < 1 implies a lower probability of being confirmed ZIKV RNA negative in vaginal secretions (increased likelihood of ZIKV persistence).
*Excluding 1 participant without rash.
ZIKV Zika virus, BMI body mass index, HR hazard ratio, CI confidence interval.