Table 1:

Common Health-Related Quality of Life Instruments Used in Studies of Patients with Cirrhosis

Instrument	Items	Domains	Scoring	Time (in minutes)	Cost
PROMIS-29, PROMIS-29+2	29 31	Physical function, Anxiety, Depression, Fatigue, Sleep, Social roles/activities, Pain interference, Pain Intensity;Cognitive Function (+2)	0–100 T-scores (compared to general US population) for each domain. The 29+2 can render a 0–100 summary score.	5.4±3.0	Free
SF-36	36	Physical function, Role limitations due to physical function, Emotional well-being, Role limitations due to emotional function, energy/fatigue, social functioning, pain, general health	0–100 scores for each domain or the physical or mental components, calibrated where 50 is the average.	6.7±3.3	Free version available
Chronic Liver Disease Questionnaire	29	Fatigue, Activity, Emotional function, abdominal symptoms, systemic symptoms, worry	6–42 overall with each of the six domains scored 1–7	6.5±5.2	License required
Sickness Impact Profile	136	Sleep and rest, Eating, work, home management, recreation, ambulation, mobility, body care and movement, social interaction, emotional behavior, and communication.	0–100 overall and for each domain	≤30	License required
SF-Liver Disease Quality of Life	72	Sexual dysfunction, stigma, hopelessness, sleep, concentration/memory, symptoms of liver disease, distress, loneliness, and SF-36	0–100 overall and for each component (LDQOL and SF-36 components)	18±9(9)	Free
Eq5D-3L or 5L	15–25	Mobility, Self-care, Usual activities, Pain / discomfort, Anxiety / Depression	0–100 overall	<3	License required, cost according to purpose
Visual Analog Scale	1	General health-related quality of life	0–100 overall	<1	Free