Figure 1.

A) The mechanical withdrawal threshold (g) in response to stimuli applied via von-Frey filament in CCI rats treated by the probiotics mixture

B) The graphs show the withdrawal frequencies following using cold stimuli (acetone) to the rats’ hind paw

C) The thermal withdrawal latency (S) in response to applying noxious radiant heat to the CCI rats’ hind paw

The behavioral responses were determined on days 1, 3, 7, 14, and 21 post-surgery. Treatment by probiotics mixture for 21 days significantly reduced elevated cold and mechanical allodynia and thermal hyperalgesia in rats’ model of chronic constriction injury of the sciatic nerve. Results are expressed as Mean±SEM and n=10 in all groups.

^***P<0.001 the CS group vs. the SM group^,###P<0.001 the CS group vs. the CP group, ^†††P<0.001 the CS group vs. the CG group.