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Calculation of the oximetry-based hypoxic burden (HB). a) All automatically detected desaturations are synchronised at their minimum saturation levels (time 0) and ensemble averaged to obtain the search window (duration between two maximum peaks around time 0). b) HB is calculated as the normalised summation of the coloured arterial oxygen saturation (SaO2) areas within the search window for all desaturation episodes divided by total sleep time.
