TABLE 2.
Cox regression models evaluating the effect of continuous positive airway pressure (CPAP) treatment on the primary end-point according to the baseline hypoxic burden (HB) level
| Events | Follow-up (months) |
Unadjusted HR
(95% CI) |
p-value |
Adjusted# HR
(95% CI) |
p-value | |
| Low HB | ||||||
| Usual care | 26 (13.9) | 33.34 (15.03–54.04) | Reference | Reference | ||
| CPAP | 31 (17.4) | 24.34 (13.80–43.37) | 1.33 (0.79–2.25) | 0.281 | 1.31 (0.78–2.22) | 0.308 |
| High HB | ||||||
| Usual care | 36 (20.3) | 24.26 (12.27–41.86) | Reference | Reference | ||
| CPAP | 24 (13.0) | 32.00 (13.27–58.22) | 0.57 (0.34–0.96) | 0.035 | 0.61 (0.36–1.03) | 0.063 |
Data are presented as n (%) or median (interquartile range), unless otherwise stated. The pre-intervention HB was categorised as “low” or “high” based on the median value (≤73.1%min·h−1 or >73.1%min·h−1, respectively). Usual care and low baseline HB are the reference categories for the CPAP and high HB groups, respectively. #: adjustment for age, sex, body mass index and previous cardiovascular disease. Significant p-values (p<0.05) are presented in bold.