TABLE 3.
Cox regression models evaluating the effect of continuous positive airway pressure (CPAP) treatment on the cardiac end-point according to the baseline hypoxic burden (HB) level
| Events | Follow-up (months) |
Unadjusted HR
(95% CI) |
p-value |
Adjusted# HR
(95% CI) |
p-value | |
| Low HB | ||||||
| Usual care | 18 (9.6) | 34.91 (16.78–55.95) | Reference | Reference | ||
| CPAP | 22 (12.4) | 25.96 (14.32–47.57) | 1.36 (0.73–2.54) | 0.331 | 1.36 (0.72–2.55) | 0.339 |
| High HB | ||||||
| Usual care | 31 (17.4) | 24.6 (12.85–47.04) | Reference | Reference | ||
| CPAP | 19 (10.3) | 34.29 (17.50–58.45) | 0.52 (0.29–0.92) | 0.025 | 0.53 (0.30–0.95) | 0.034 |
Data are presented as n (%) or median (interquartile range), unless otherwise stated. The pre-intervention HB was categorised as “low” or “high” based on the median value (≤73.1%min·h−1 or >73.1%min·h−1, respectively). Usual care and low baseline HB are the reference categories for the CPAP and high HB groups, respectively. #: adjustment for age, sex, body mass index and previous cardiovascular disease. Significant p-values (p<0.05) are presented in bold.