Fig. 1.

DegronMD workflow for data collection, processing, methodology, and database construction. a) Identification of new degrons in the human proteome through pattern recognition and machine learning technique. b) Five functional outcomes for degron-related mutations. c) DegMF method for quantifying the impact of missense mutations on degron function based on the observed phenotypic changes. d) The strategy for detecting drug resistance potentially caused by degron mutations. e) Construction of DegronMD database.