Table 2.

NOD-like receptor pyrin domain containing 3 inflammasome inhibitors currently not investigated in the context of diabetic wound healing

Inhibitor	Mechanism	Study Type	Reference
Bot-4-one	NACHT ATPase inhibitor	In vitro, in vivo	77
CY-09	NACHT ATPase inhibitor: binds Walker A motif	In vitro, in vivo	78
INF39	NACHT ATPase inhibitor	In vitro, in vivo	79
MNS	NACHT ATPase inhibitor	In vitro, in vivo	80
OLT1177	NACHT ATPase inhibitor	In vitro, in vivo, clinical	81
Oridonin	Binds NLRP3 Cys279: inhibits NLRP3-NEK7 interaction	In vitro, in vivo	82
Parthenolide	NACHT ATPase inhibitor, caspase-1 inhibitor	In vitro, in vivo	78

NEK7, NIMA-related kinase 7.